Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature Pmc

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However, testosterone in physiologic doses might even be beneficial in sufferers with angina , have higher ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in men with established coronary artery disease . Therefore, an interaction of endogenous factors of the patient’s danger profile as nicely as the testosterone dosing may be issues of whether adverse events happen. Erythrocytosis has been reported as a possible effect of testosterone, which could be useful in sufferers with anemia.

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• Rhoden EL, Morgentaler A. Risks of testosterone-replacement remedy and proposals for monitoring.
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• Erythrocytosis has been reported as a potential effect of testosterone, which may be helpful in sufferers with anemia.

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Patients also may be taking concomitant stimulants, similar to ephedra, which might confound data and the potential for opposed occasions. It is probably going that the frequency of cardiac events is underreported within the medical literature. Moreover, testosterone has been used within the therapy of decreased muscle mass and bone density in addition to anemia. The function testosterone could play within the development of cardiovascular disease has increasingly turn into the topic of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 pure and synthetic derivatives of testosterone, might trigger a wide spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical practice recently. Other common potential antagonistic effects embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .

Dialogue And Review Of The Literature

We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac danger factors utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, probably secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the right coronary artery. Physicians and patients should concentrate on the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.

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