Blood viscosity and you will hypertension: character out of temperatures and hyperglycemia
Yildirim Cinar, A good. Mete Senyol, Kamber Duman, Bloodstream viscosity and you can blood pressure levels: role out of temperature and hyperglycemia, Western Diary off Blood pressure, Frequency fourteen, Point 5, , Pages 433–438,
Conceptual
We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.
The aim of the investigation is to try to look into the dating among temperatures, glucose amount, and viscosity from bloodstream and you can plasma, in order to assess their outcomes into the blood circulation pressure (BP) based on Hagen-Poiseuille’s hydrodynamics formula.
If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F1 ? F2) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F1 ? F2), where ? is the viscosity of the fluid, F1 and F2 are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.
Bloodstream viscosity and blood pressure level: part of heat and you may hyperglycemia
It’s been shown that ranging from % and % opinions away from hematocrit, most of the eleven% escalation in hematocrit grows bloodstream viscosity from the 20%. In this condition, based on Poiseuille’s picture, blood supply price reduces from the %, which may result in cells ischemia. To keep the fresh new circulatory program into the equilibrium (that’s, remaining new flow rate adequate and you may blocking muscle ischemia), good 20% rise in BP otherwise cuatro.66% vasodilation is required. step 3 Yet not, the human circulatory experience perhaps not an accurate closed program, as the bloodstream viscosity can be changed into absorption of dinner otherwise pills. 4–8 In addition, the effects out of dietary fat and of some medications with the bloodstream viscosity and you can hemodynamics particularly BP were said. As atherosclerotic boats never dilate sufficiently given that a reaction to vasodilator medication, it’s been advised one increased blood viscosity can just only end up being settled having an excellent hookup on craigslist BP boost in eg issues. 9–12 As well as, new dating certainly BP, nightmare, coagulation, blood circulation acceleration, and bloodstream viscosity have been described through the principles regarding hemodynamics. thirteen, 14
